Rescue workers were searching through the night Wednesday, nearly 24 hours after at least 159 people were killed and hundreds of others were injured by a powerful earthquake that destroyed a cluster of small mountain villages in central Italy.

Italy’s health minister, Beatrice Lorenzin, said that many of the victims were children. Premier Matteo Renzi said the death toll was likely to rise. At least 368 people were injured.

“She’s alive!” two women cheered as they ran up the street in Pescara del Tronto, one of the three hardest hit hamlets, after a 10-year-old girl was pulled from the rubble after nightfall Wednesday.

“Unfortunately, 90 percent we pull out are dead, but some make it, that’s why we are here,” said Christian Bianchetti, a volunteer from Rieti working in the village of Amatrice, where flood lights were set up so the rescue could continue through Wednesday night.

Amatrice, a village of 2,700 about 60 miles northeast of Rome, was devastated by the magnitude-6.2 quake, which struck at 3:36 a.m. local time and was felt as far away as the Italian capital.

“The town isn’t here anymore,” said Amatrice Mayor Sergio Pirozzi.

“We came out to the piazza, and it looked like Dante’s Inferno,” said Agostino Severo, a Rome resident visiting Illica. “People [were] crying for help, help. Rescue workers arrived after one hour … one and a half hours.”

The temblor shook the Lazio region and Umbria and Le Marche on the Adriatic coast, a highly seismic area that has witnessed major quakes in the past. 

The area is also a popular spot for Romans with second homes, and the population swells in August when most Italians take their summer holiday before school resumes.

In addition, Amatrice was full for a planned weekend festival honoring its native dish, the spaghetti all’amatriciana bacon and tomato sauce. Some 70 guests filled its top Hotel Roma, famed for its amatriciana, and a rescue worker said at least five bodies were pulled from the hotel’s rubble. The fate of the dozens of other guests wasn’t immediately known.

Italy’s civil protection agency set up tent cities around each hamlet to accommodate the thousands of homeless.

The medieval center of Amatrice was devastated, with the hardest-hit half of the city cut off by rescue crews digging by hand to get to trapped residents.

Amatrice is made up of 69 hamlets that teams from around Italy were working to reach with sniffer dogs, earth movers and other heavy equipment to reach residents. In the city center, rocks and metal tumbled onto the streets and dazed residents huddled in piazzas as more than 200 aftershocks jolted the region throughout the day, some as strong as magnitude-5.1.

“The whole ceiling fell but did not hit me,” marveled resident Maria Gianni. “I just managed to put a pillow on my head and I wasn’t hit, luckily, just slightly injured my leg.”

Another woman, sitting in front of her destroyed home with a blanket over her shoulders, said she didn’t know what had become of her loved ones.

“It was one of the most beautiful towns of Italy and now there’s nothing left,” she said, too distraught to give her name. “I don’t know what we’ll do.”

As the August sun turned into a nighttime chill, residents, civil protection workers and even priests dug with shovels, bulldozers and their bare hands to reach survivors. A steady column of dump trucks brought tons of twisted metal, rock and cement down the hill and onto the highway toward Rome, along with a handful of ambulances bringing the injured to Rome hospitals.

“We need chain saws, shears to cut iron bars and jacks to remove beams. Everything, we need everything,” civil protection worker Andrea Gentili told The Associated Press in the early hours of the recovery. Italy’s national blood drive association appealed for donations to Rieti’s hospital.

Despite a massive rescue and relief effort — with army, Alpine crews, carabineri, firefighters, Red Cross crews and volunteers, it wasn’t enough: A few miles north of Amatrice, in Illica, residents complained that rescue workers were slow to arrive and that loved ones were trapped.

“We are waiting for the military,” said resident Alessandra Cappellanti. “There is a base in Ascoli, one in Rieti, and in L’Aquila. And we have not seen a single soldier. We pay! It’s disgusting!”

The U.S. Geological Survey reported the quake’s magnitude was 6.2, while the Italian geological service put it at 6 and the European Mediterranean Seismological Center at 6.1. The quake had a shallow depth of between 2.5 and six miles, the agencies said. Generally, shallow earthquakes pack a bigger punch and tend to be more damaging than deeper quakes.

“The Apennine mountains in central Italy have the highest seismic hazard in Western Europe and earthquakes of this magnitude are common,” noted Dr Richard Walters, a lecturer in Earth sciences at Durham University in Britain.

The devastation harked back to the 2009 quake that killed more than 300 people in and around L’Aquila, about 55 miles south of the latest quake. The town, which still hasn’t fully recovered, sent emergency teams Wednesday to help with the rescue and set up tent camps for residents unwilling to stay indoors because of aftershocks.

“I don’t know what to say. We are living this immense tragedy,” said a tearful Rev. Savino D’Amelio, a parish priest in Amatrice. “We are only hoping there will be the least number of victims possible and that we all have the courage to move on.”

In Pescara del Tronto, where the main road was covered in debris, residents were digging their neighbors out by hand before emergency crews arrived. Aerial photos taken by regional firefighters showed the town essentially flattened and under a thick gray coat of dust; Italy requested EU satellite images of the whole area to get the scope of the damage.

“There are broken liquor bottles all over the place,” said Gino Petrucci, owner of a bar in nearby Arquata Del Tronto where he was beginning the long cleanup.

One rescue was particularly delicate as a ranger in Capodacqua, in the Marche province of Ascoli Piceno, diplomatically tried to keep an 80-year-old woman calm as she begged to get to a toilet, even though she was trapped in the rubble.

“Listen, I know it’s not nice to say but if you need to pee you just do it,” he said. “Now I move away a little bit and you do pee, please.”

The mayor of Accumoli, Stefano Petrucci, said a family of four had died there, one of the few young families who had decided to stay in the area. He wept as he noted that the tiny hamlet of 700 swells to 2,000 in the summer months, and that he feared for the future of the town.

“I hope they don’t forget us,” he told Sky TG24.

President Barack Obama, speaking by telephone to Italian President Sergio Mattarella, said the U.S. sent its thoughts and prayers to the quake victims and saluted the “quick action” by first responders, White House spokesman Josh Earnest said.

A 1997 quake killed a dozen people in central Italy and severely damaged one of the jewels of Umbria, the Basilica of St. Francis in Assisi, filled with Giotto frescoes. The Franciscan friars who are the custodians of the basilica reported no immediate damage from Wednesday’s temblor.

Pope Francis skipped his traditional catechism for his Wednesday general audience and instead invited the thousands of pilgrims in St. Peter’s Square to recite the rosary with him. He also sent a six-man squad from the Vatican’s fire department to help with the rescue.

The Associated Press contributed to this report.